Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Shh  sonic hedgehog   (Synonyms: Hhg1)
Results	Reference
1	J:37641 Ahlgren U, Pfaff SL, Jessell TM, Edlund T, Edlund H, Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature. 1997 Jan 16;385(6613):257-60
1	J:173604 Allen BL, Song JY, Izzi L, Althaus IW, Kang JS, Charron F, Krauss RS, McMahon AP, Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function. Dev Cell. 2011 Jun 14;20(6):775-87
1	J:273860 Andreu-Cervera A, Anselme I, Karam A, Laclef C, Catala M, Schneider-Maunoury S, The Ciliopathy Gene Ftm/Rpgrip1l Controls Mouse Forebrain Patterning via Region-Specific Modulation of Hedgehog/Gli Signaling. J Neurosci. 2019 Mar 27;39(13):2398-2415
1	J:145732 Aoto K, Shikata Y, Imai H, Matsumaru D, Tokunaga T, Shioda S, Yamada G, Motoyama J, Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis. Dev Biol. 2009 Mar 1;327(1):106-20
1	J:186055 Ashique AM, Choe Y, Karlen M, May SR, Phamluong K, Solloway MJ, Ericson J, Peterson AS, The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis. Sci Signal. 2009;2(95):ra70
1	J:110211 Baek JH, Hatakeyama J, Sakamoto S, Ohtsuka T, Kageyama R, Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system. Development. 2006 Jul;133(13):2467-76
1*	J:79392 Bai CB, Auerbach W, Lee JS, Stephen D, Joyner AL, Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development. 2002 Oct;129(20):4753-61
1	J:259558 Bhattacharyya S, Rainey MA, Arya P, Dutta S, George M, Storck MD, McComb RD, Muirhead D, Todd GL, Gould K, Datta K, Gelineau-van Waes J, Band V, Band H, Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development. Sci Rep. 2016 Feb 17;6:20727
1	J:245758 Carreno G, Apps JR, Lodge EJ, Panousopoulos L, Haston S, Gonzalez-Meljem JM, Hahn H, Andoniadou CL, Martinez-Barbera JP, Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors. Development. 2017 Sep 15;144(18):3289-3302
1*	J:79027 Caspary T, Garcia-Garcia MJ, Huangfu D, Eggenschwiler JT, Wyler MR, Rakeman AS, Alcorn HL, Anderson KV, Mouse dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling. Curr Biol. 2002 Sep 17;12(18):1628-32
1	J:138713 Cho A, Ko HW, Eggenschwiler JT, FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol. 2008 Sep 1;321(1):27-39
1*	J:85473 Corbin JG, Rutlin M, Gaiano N, Fishell G, Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning. Development. 2003 Oct;130(20):4895-906
1	J:190013 Dennis JF, Kurosaka H, Iulianella A, Pace J, Thomas N, Beckham S, Williams T, Trainor PA, Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. PLoS Genet. 2012 Oct;8(10):e1002927
1*	J:104803 Eggenschwiler JT, Bulgakov OV, Qin J, Li T, Anderson KV, Mouse Rab23 regulates Hedgehog signaling from Smoothened to Gli proteins. Dev Biol. 2006 Feb 1;290(1):1-12
1*	J:215449 Eguether T, San Agustin JT, Keady BT, Jonassen JA, Liang Y, Francis R, Tobita K, Johnson CA, Abdelhamed ZA, Lo CW, Pazour GJ, IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment. Dev Cell. 2014;31:279-290
1	J:152551 Endoh-Yamagami S, Evangelista M, Wilson D, Wen X, Theunissen JW, Phamluong K, Davis M, Scales SJ, Solloway MJ, de Sauvage FJ, Peterson AS, The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol. 2009 Aug 11;19(15):1320-6
1	J:290813 Fiore L, Takata N, Acosta S, Ma W, Pandit T, Oxendine M, Oliver G, Optic vesicle morphogenesis requires primary cilia. Dev Biol. 2020 Jun 15;462(2):119-128
1	J:159118 Fotopoulou S, Oikonomou N, Grigorieva E, Nikitopoulou I, Paparountas T, Thanassopoulou A, Zhao Z, Xu Y, Kontoyiannis DL, Remboutsika E, Aidinis V, ATX expression and LPA signalling are vital for the development of the nervous system. Dev Biol. 2010 Mar 15;339(2):451-64
1	J:226733 Franco I, Gulluni F, Campa CC, Costa C, Margaria JP, Ciraolo E, Martini M, Monteyne D, De Luca E, Germena G, Posor Y, Maffucci T, Marengo S, Haucke V, Falasca M, Perez-Morga D, Boletta A, Merlo GR, Hirsch E, PI3K class II alpha controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function. Dev Cell. 2014 Mar 31;28(6):647-58
1	J:155627 Genethliou N, Panayiotou E, Panayi H, Orford M, Mean R, Lapathitis G, Gill H, Raoof S, De Gasperi R, Elder G, Kessaris N, Richardson WD, Malas S, SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1114-20
1	J:147382 Genethliou N, Panayiotou E, Panayi H, Orford M, Mean R, Lapathitis G, Malas S, Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord. Biochem Biophys Res Commun. 2009 Apr 24;382(1):69-73
1	J:140315 Geng X, Speirs C, Lagutin O, Inbal A, Liu W, Solnica-Krezel L, Jeong Y, Epstein DJ, Oliver G, Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell. 2008 Aug;15(2):236-47
1*	J:287091 Gigante ED, Taylor MR, Ivanova AA, Kahn RA, Caspary T, ARL13B regulates Sonic hedgehog signaling from outside primary cilia. Elife. 2020 Mar 4;9:e50434
1	J:71184 Gritli-Linde A, Lewis P, McMahon AP, Linde A, The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol. 2001 Aug 15;236(2):364-86
1	J:344557 Hall ET, Dillard ME, Cleverdon ER, Zhang Y, Daly CA, Ansari SS, Wakefield R, Stewart DP, Pruett-Miller SM, Lavado A, Carisey AF, Johnson A, Wang YD, Selner E, Tanes M, Ryu YS, Robinson CG, Steinberg J, Ogden SK, Cytoneme signaling provides essential contributions to mammalian tissue patterning. Cell. 2024 Jan 18;187(2):276-293.e23
1*	J:241009 Himmelstein DS, Cajigas I, Bi C, Clark BS, Van Der Voort G, Kohtz JD, SHH E176/E177-Zn2+ conformation is required for signaling at endogenous sites. Dev Biol. 2017 Apr 15;424(2):221-235
1*	J:141306 Hsu CY, Chang NC, Lee MW, Lee KH, Sun DS, Lai C, Chang AC, LUZP deficiency affects neural tube closure during brain development. Biochem Biophys Res Commun. 2008 Nov 21;376(3):466-71
1	J:86437 Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV, Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003 Nov 6;426(6962):83-7
1*	J:292838 Iulianella A, Stanton-Turcotte D, The Hedgehog receptor Patched1 regulates proliferation, neurogenesis, and axon guidance in the embryonic spinal cord. Mech Dev. 2019 Dec;160:103577
1	J:128441 Jacob J, Ferri AL, Milton C, Prin F, Pla P, Lin W, Gavalas A, Ang SL, Briscoe J, Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci. 2007 Nov;10(11):1433-9
1	J:258267 Jovanovic VM, Salti A, Tilleman H, Zega K, Jukic MM, Zou H, Friedel RH, Prakash N, Blaess S, Edenhofer F, Brodski C, BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells. J Neurosci. 2018 Feb 14;38(7):1662-1676
1*	J:200761 Kasberg AD, Brunskill EW, Steven Potter S, SP8 regulates signaling centers during craniofacial development. Dev Biol. 2013 Sep 15;381(2):312-23
1*	J:79831 Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang PT, Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development. 2002 Dec;129(24):5753-65
1	J:184749 Keady BT, Samtani R, Tobita K, Tsuchya M, San Agustin JT, Follit JA, Jonassen JA, Subramanian R, Lo CW, Pazour GJ, IFT25 Links the Signal-Dependent Movement of Hedgehog Components to Intraflagellar Transport. Dev Cell. 2012 May 15;22(5):940-51
1	J:291852 Kim Y, Lee J, Seppala M, Cobourne MT, Kim SH, Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration. Nat Commun. 2020 Apr 24;11(1):1994
1	J:130846 Kittappa R, Chang WW, Awatramani RB, McKay RD, The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol. 2007 Dec;5(12):e325
1*	J:158583 Ko HW, Norman RX, Tran J, Fuller KP, Fukuda M, Eggenschwiler JT, Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev Cell. 2010 Feb 16;18(2):237-47
1	J:225071 Law KK, Makino S, Mo R, Zhang X, Puviindran V, Hui CC, Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling. PLoS One. 2012;7(11):e50193
1	J:92067 Lei Q, Zelman AK, Kuang E, Li S, Matise MP, Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development. 2004 Aug;131(15):3593-604
1	J:142133 Li Y, Gordon J, Manley NR, Litingtung Y, Chiang C, Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. Dev Biol. 2008 Oct 1;322(1):145-55
1	J:152413 Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH, Ang SL, Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. Dev Biol. 2009 Sep 15;333(2):386-96
1*	J:314133 Marczenke M, Sunaga-Franze DY, Popp O, Althaus IW, Sauer S, Mertins P, Christ A, Allen BL, Willnow TE, GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium. Development. 2021 Nov 1;148(21):dev200080
1	J:122795 Maria Fimia G, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R, Corazzari M, Fuoco C, Ucar A, Schwartz P, Gruss P, Piacentini M, Chowdhury K, Cecconi F, Ambra1 regulates autophagy and development of the nervous system. Nature. 2007 Jun 28;447(7148):1121-5
1*	J:28010 Marti E, Takada R, Bumcrot DA, Sasaki H, McMahon AP, Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development. 1995 Aug;121(8):2537-47
1	J:121554 Martinelli DC, Fan CM, Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev. 2007 May 15;21(10):1231-43
1*	J:49251 Matise MP, Epstein DJ, Park HL, Platt KA, Joyner AL, Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development. 1998 Aug;125(15):2759-70
1*	J:170258 Mavromatakis YE, Lin W, Metzakopian E, Ferri AL, Yan CH, Sasaki H, Whisett J, Ang SL, Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity. Mech Dev. 2011 Jan-Feb;128(1-2):90-103
1*	J:84056 Motoyama J, Milenkovic L, Iwama M, Shikata Y, Scott MP, Hui CC, Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev Biol. 2003 Jul 1;259(1):150-61
1	J:273907 Nandadasa S, Kraft CM, Wang LW, O'Donnell A, Patel R, Gee HY, Grobe K, Cox TC, Hildebrandt F, Apte SS, Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis. Nat Commun. 2019 Feb 27;10(1):953
1	J:160534 Ono Y, Nakatani T, Minaki Y, Kumai M, The basic helix-loop-helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells. Development. 2010 Jun;137(11):1897-906
1*	J:234927 Orquera DP, Nasif S, Low MJ, Rubinstein M, de Souza FS, Essential function of the transcription factor Rax in the early patterning of the mammalian hypothalamus. Dev Biol. 2016 Aug 1;416(1):212-24
1	J:196506 Pasek RC, Berbari NF, Lewis WR, Kesterson RA, Yoder BK, Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis. Cilia. 2012;1(1):20
1	J:104370 Prakash N, Brodski C, Naserke T, Puelles E, Gogoi R, Hall A, Panhuysen M, Echevarria D, Sussel L, Weisenhorn DM, Martinez S, Arenas E, Simeone A, Wurst W, A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development. 2006 Jan;133(1):89-98
1	J:85954 Qu J, Li X, Novitch BG, Zheng Y, Kohn M, Xie JM, Kozinn S, Bronson R, Beg AA, Minden A, PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol. 2003 Oct;23(20):7122-33
1	J:111617 Que J, Choi M, Ziel JW, Klingensmith J, Hogan BL, Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps. Differentiation. 2006 Sep;74(7):422-37
1*	J:103820 Reiter JF, Skarnes WC, Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev. 2006 Jan 1;20(1):22-7
1*	J:160812 Ribes V, Balaskas N, Sasai N, Cruz C, Dessaud E, Cayuso J, Tozer S, Yang LL, Novitch B, Marti E, Briscoe J, Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev. 2010 Jun 1;24(11):1186-200
1	J:144016 Ribes V, Le Roux I, Rhinn M, Schuhbaur B, Dolle P, Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways. Development. 2009 Feb;136(4):665-76
1	J:79100 Riccomagno MM, Martinu L, Mulheisen M, Wu DK, Epstein DJ, Specification of the mammalian cochlea is dependent on Sonic hedgehog. Genes Dev. 2002 Sep 15;16(18):2365-78
1	J:222417 Sloan TF, Qasaimeh MA, Juncker D, Yam PT, Charron F, Integration of shallow gradients of Shh and Netrin-1 guides commissural axons. PLoS Biol. 2015 Mar;13(3):e1002119
1	J:239945 Souilhol C, Perea-Gomez A, Camus A, Beck-Cormier S, Vandormael-Pournin S, Escande M, Collignon J, Cohen-Tannoudji M, NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo. Development. 2015 Nov 01;142(21):3649-60
1	J:105832 Svard J, Henricson KH, Persson-Lek M, Rozell B, Lauth M, Bergstrom A, Ericson J, Toftgard R, Teglund S, Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway. Dev Cell. 2006 Feb;10(2):187-97
1	J:199133 Tang M, Luo SX, Tang V, Huang EJ, Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development. Neural Dev. 2013;8:8
1	J:147427 Vue TY, Bluske K, Alishahi A, Yang LL, Koyano-Nakagawa N, Novitch B, Nakagawa Y, Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. J Neurosci. 2009 Apr 8;29(14):4484-97
1	J:228522 Yang SL, Yang M, Herrlinger S, Liang C, Lai F, Chen JF, MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation. Dev Biol. 2015 Dec 1;408(1):140-50
1	J:143585 Yu W, McDonnell K, Taketo MM, Bai CB, Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner. Development. 2008 Nov;135(22):3687-96
1	J:154982 Yun S, Saijoh Y, Hirokawa KE, Kopinke D, Murtaugh LC, Monuki ES, Levine EM, Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development. 2009 Dec;136(23):3895-906
1	J:315090 Zhang Z, Shen L, Law K, Zhang Z, Liu X, Hua H, Li S, Huang H, Yue S, Hui CC, Cheng SY, Suppressor of Fused Chaperones Gli Proteins To Generate Transcriptional Responses to Sonic Hedgehog Signaling. Mol Cell Biol. 2017 Feb 1;37(3)